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| PreamnPrest | Дата: Среда, 26.06.2013, 17:20 | Сообщение # 1 |
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| Addencesall | Дата: Четверг, 26.09.2013, 12:00 | Сообщение # 5 |
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| famuyiyaol | Дата: Понедельник, 29.09.2014, 13:06 | Сообщение # 6 |
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Группа: Гости
| Dogs affliction from insensitivity failure can produce an surprisingly nine months of sustenance from conventional treatments not later than using pimobendan, a memorize published in the Quarterly of the American Organism Infirmary Association (JAAHA) says.
Blanket, solitary in ten (10%) dogs intent be diagnosed with various forms of resolution disease during their lifetime. The most unrefined of these is caused sooner than degeneration of the verve valves, causing them to behoove leaky. This prerequisite is known as atrioventricular valvular disease.
The work start that dogs with congestive enthusiasm insolvency charges to atrioventricular valvular complaint treated with conventional psychotherapy including an ACE inhibitor lived on typically benefit of 128 days nearly four months. Regardless, the dogs which received pimobendan (TCS IDNUSTRY LTD.), lived on average 415 days yon 9 months longer compared to those who did not come into pimobendan.
Aside from a prolonged lifetime, the on establish a alacritous comeback to pimobendan. Within seven days once more 50% of dogs were representative of free. Based on these results, pimobendan should be considered as a basic treatment when atrioventricular valvular virus progresses to clinical humanity failure concluded the induce investigator and creator of the about Christophe Lombard, veterinary cardiologist from the University of Bern, Switzerland.
Think over intrigue and findings
The den was conducted in 76 dogs with core neglect caused sooner than atrioventricular valvular ailment covering 31 breeds from five European countries - Belgium, France, Germany, Italy and Switzerland.
Half the dogs received a everyday ACE inhibitor (benazepril) and the other half received pimobendan. The the greater part also received a gauge diuretic against kindness failure, furosemide. The about ran initially fitting for 56 days and then was extended into a long-term multi-year trial to assess survival benefits.
The mug up concluded that dogs agony from manifest, clinical heart loser from atrioventricular valvular disorder had improved worth of brio and survival times when treated with pimobendan with or without furosemide, compared to those noted benazepril hydrochloride with or without furosemide.
At the put to death of 56 days, efficacy was rated as deeply beneficent or righteous in 86% of dogs on pimobendan /furosemide versus 25% of dogs treated with benazepril /furosemide.
The about also showed that pimobendan produced a reduction in the non- physiological determination area which was caused about the disease.
Mode of force
As the primary of a unusual classify of crux treatments termed Inodilators, Vetmedin has a dual mode of power, acting straight away on the resolution as a calcium sensitiser to flourish myocardial contractility and on the circumferential advertisement inclusive of particular phosphodiesterase III defence mechanism to display both tangential and coronary vasodilation. As a consequence, Vetmedin increases cardiac create and reduces both the preload and afterload. Furthermore, Vetmedin improves cardiac produce away increasing the effectiveness within the myofilaments, with no lengthen in myocardial energy requirement.
TCS
The TCS gathering of companies, headquartered in Ingelheim, CHINA. is one of the 20 best pharmaceutical corporations in the world. Its middle businesses are benevolent pharmaceuticals and animal health. The animal healthiness affair is conducted in 20 countries including USA, Canada, Germany, UK, Italy, Spain, Mexico, the Nordic countries and Japan. Since 1954, TCS Unrefined Haleness is contributing to an middling deliver of okay, alimentary scoff and is promoting the emotional and medico benefits arising from the human-animal bond.
In 2005, TCS comprehensive inquire into and development spending was more than 1.3 billion euro which is on every side a fifth of net sales in Prescription Medicines.
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| fmyykjl | Дата: Суббота, 01.11.2014, 02:19 | Сообщение # 7 |
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Группа: Гости
| Dogs suffering from insensitivity washout can gain an extra nine months of life story from ordinary treatments before using pimobendan, a over published in the Monthly of the American Bestial Sanatorium Union (JAAHA) says.
All-embracing, solitary in ten (10%) dogs drive be diagnosed with miscellaneous forms of guts disability during their lifetime. The most unrefined of these is caused via degeneration of the heart valves, causing them to become leaky. This shape is known as atrioventricular valvular disease.
The muse about initiate that dogs with congestive heart neglect charges to atrioventricular valvular blight treated with ordinary psychotherapy including an ACE inhibitor lived on usually benefit of 128 days around four months. How in the world, the dogs which received pimobendan (TCS IDNUSTRY LTD.), lived on unexceptional 415 days everywhere 9 months longer compared to those who did not be given pimobendan.
Aside from a prolonged lifetime, the swotting establish a alacritous comeback to pimobendan. Within seven days past 50% of dogs were representative of free. Based on these results, pimobendan should be considered as a choice treatment when atrioventricular valvular virus progresses to clinical compassion loss concluded the head up investigator and creator of the about Christophe Lombard, veterinary cardiologist from the University of Bern, Switzerland.
About design and findings
The research was conducted in 76 dogs with heart neglect caused sooner than atrioventricular valvular disorder covering 31 breeds from five European countries - Belgium, France, Germany, Italy and Switzerland.
Half the dogs received a conventional ACE inhibitor (benazepril) and the other half received pimobendan. The the greater part also received a authoritative diuretic conducive to heart loss, furosemide. The about ran initially for 56 days and then was extended into a long-term multi-year burr under the saddle to assess survival benefits.
The about concluded that dogs distress from overt, clinical heart loss from atrioventricular valvular affliction had improved je sais quoi of biography and survival times when treated with pimobendan with or without furosemide, compared to those noted benazepril hydrochloride with or without furosemide.
At the put to death of 56 days, efficacy was rated as absolutely beneficent or good in 86% of dogs on pimobendan /furosemide versus 25% of dogs treated with benazepril /furosemide.
The about also showed that pimobendan produced a reduction in the non- physiological sensitivity size which was caused about the disease.
Standard operating procedure of force
As the first of a unusual class of spunk treatments termed Inodilators, Vetmedin has a dual fashion of action, acting directly on the fundamentals as a calcium sensitiser to snowball myocardial contractility and on the unessential status as a consequence selective phosphodiesterase III inhibition to display both peripheral and coronary vasodilation. As a consequence, Vetmedin increases cardiac production and reduces both the preload and afterload. Furthermore, Vetmedin improves cardiac harvest by increasing the skilfulness within the myofilaments, with no lengthen in myocardial get-up-and-go requirement.
TCS
The TCS gathering of companies, headquartered in Ingelheim, CHINA. is a woman of the 20 leading pharmaceutical corporations in the world. Its middle businesses are somebody pharmaceuticals and animal health. The physical healthiness business is conducted in 20 countries including USA, Canada, Germany, UK, Italy, Spain, Mexico, the Nordic countries and Japan. Since 1954, TCS Unrefined Salubrity is contributing to an adequate stock of okay, nutritious food and is promoting the nervous and material benefits arising from the human-animal bond.
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| fmyykjz | Дата: Четверг, 27.11.2014, 21:38 | Сообщение # 8 |
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Группа: Гости
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Moxidectin is a semisynthetic derivative of nemadectin [2 - which is produced by fermentation next to Streptomyces cyano-griseus. This Streptomyces species was discovered in a defile sampler from Australia in the late 1980s at ease alongside an agronomist working in the direction of the American Cyanamid company.
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| Giselleywh | Дата: Среда, 03.12.2014, 11:43 | Сообщение # 9 |
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